Two sample MR report
NQO2_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 0.1095553 | 0.0621087 | 0.1082129 |
| Weighted median | 12 | 0.0400630 | 0.0075967 | 0.0000001 |
| Inverse variance weighted | 12 | 0.0366484 | 0.0062468 | 0.0000000 |
| Simple mode | 12 | 0.0391868 | 0.0106154 | 0.0035539 |
| Weighted mode | 12 | 0.0394135 | 0.0101174 | 0.0024954 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 11.52449 | 10 | 0.3181397 |
| Inverse variance weighted | 13.12816 | 11 | 0.2850315 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0474319 | 0.0402091 | 0.2654482 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001993 | 0 | TRUE | 0.1847096 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
